期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 31, 期 16, 页码 2025-2043出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2020.1793464
关键词
Antimicrobial; chitooligosaccharide; silver nanoparticle
资金
- Teachers Associateship for Research Excellence (TARE), Department of Science and Technology, and Science and Engineering Research Board (DST-SERB), Government of India, New Delhi [TAR/2018/001196]
Scaffolding system plays an important role in the development of artificial bone for treatment of defective or diseased bone tissue. In the present work, we have developed microspheres (COS-Ag-Alg-HA) containing chitooligosaccharide (COS) coated silver nanoparticles (Ag NPs) with alginate (Alg) and hydroxyapatite (HA) as bone graft substitutes. The developed microspheres were characterized through various analytical techniques such as UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction, field emission scanning electron microscopy with EDX and evaluated the mechanical strength by using universal testing machine. In addition to this, antimicrobial activity and biocompatibility of the developed microspheres were evaluated with pathogenic microbes and osteoblast-like cells, respectively. Results suggest that microspheres are rigid, and strong chemical interactions were observed between the materials. The size of the microspheres was ranging from 1.5 +/- 0.5 to 4.0 +/- 0.5 mm. Significant microbial inhibition was observed againstStaphylococcus aureus, and the developed microspheres are biocompatible with osteoblast-like cells. Based on the aforementioned finding results, the developed microsphere is proposed to be a potential candidate for bone tissue repair and regeneration.
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