期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 31, 期 15, 页码 1961-1976出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2020.1787602
关键词
Molecular imprinting; bacterial cellulose; sustained-release; drug delivery; quercetin
资金
- Walailak University [WU-IRG-62-014]
- new strategic research (P2P) project, Walailak University, Thailand
Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery. In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule. The phase inversion method was successfully used to prepare molecularly imprinted BC (MI-BC). The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated. MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did. The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com). MI-BC-com released quercetin approximately two times more slowly than NI-BC-com did at the final hour of the drug release study. The mechanism of quercetin release followed the Higuchi model. Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据