4.1 Article

A facile chemical cross-linking approach toward the fabrication of a sustainable porous ulvan scaffold

期刊

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 35, 期 4-5, 页码 301-313

出版社

SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911520939986

关键词

Biopolymer; macromolecular carbohydrates; scaffold; seaweeds; ulvan

资金

  1. DSIR PACE [DSIR/PACE/TDD/APPL/17/2013-14]
  2. CSIR-CSMCRI central facility

向作者/读者索取更多资源

Ulvans represent one of the most abundant marine-derived macromolecular sulfated polysaccharides accounting for numerous biological applications including in one of the fastest growing field of biomedical sciences. Tissue engineering based on biologically inspired and naturally derived polymers has been one of the prime focuses of regenerative medicine. The present investigation is intended to explore an ionic cross-linking approach at higher pH lead by the calcium ions for casting cell growth promoting scaffolds out of the raw ulvan. The characterization studies using attenuated total reflectance infrared spectroscopy represent specific absorptions at 2950, 980, and 600 cm(-1), whereas the x-ray diffraction showed a total absence of major crystalline peaks presenting significant shift to an amorphous state. The(1)H nuclear magnetic resonance study revealed functional group modifications in the backbone that might be potentially derived from calcium interactions with glucurorhamnose 3-sulfate and iduronorhamnose 3-sulfate. The atomic force microscopy together with field emission scanning electron microscopy and energy dispersive x-ray spectroscopy mapping revealed the resultant surface changes, whereas confocal microscopy z-stacking showed the cell proliferative activity as evident by the attainment of complete morphology. The combined chemical and biological response of the scaffold makes it a well suitable support for its cell culture and tissue engineering applications.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据