Anthraquinone analogues with inhibitory activities against influenza a virus fromPolygonatum odoratum

Three anthraquinone analogues (1-3) were isolated by phytochemical work on EtOAc-soluble ingredients extracted from the roots ofPolygonatum odoratum. The structures of all isolates were elucidated by NMR, MS and CD experiments, of which1(polygodoquinone A) was identified as a new anthraquinone derivative. Specifically,1represents an unusual structure composed of a naphthoquinone derivative linked to an anthraquinone via a C-C bond.1-3exhibited remarkable influenza A virus inhibitory activity with IC(50)values of 11.4, 11.0, and 2.3 mu M, respectively, which were better than ribavirin as the positive control.

Automated summary

Three anthraquinone analogues were isolated from the roots of Polygonatum odoratum, and one of them was identified as a new anthraquinone derivative with unusual structure. These compounds exhibited significant influenza virus inhibitory activity, with IC(50) values better than ribavirin.