期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 138, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/app.49751
关键词
biodegradable; biomaterials; degradation
资金
- Key R&D Project of Sichuan Science and Technology Department [19ZDYF1789]
- Key R&D Project of Sichuan Science and Technology Department Program [19ZDYF1147]
- National Hightech Research and Development Program [2015AA033605]
- National Natural Science Foundation of China [51772194]
This study fabricated a composite with different surface bioactivity of BG/PAA through in-situ melting polymerization, showing excellent biocompatibility and bioactivity, which has the potential for application in bone implants.
Bioglass (BG) possesses excellent bioactivity and has been widely used in the manufacture of biomaterials. In this study, a composite with different surface bioactivity was fabricated via in situ melting polymerization by incorporating BG and poly(amino acid) (PAA) at a suitable ratio. The structure of the composite was characterized by Fourier transform infrared spectroscopy and XRD. The compressive strength of the BG/PAA composites was 139 MPa (BG:PAA = 30:70). The BG/PAA composites were degradable, and higher BG in composite showed higher weight loss after 4 weeks of incubation in simulated body fluid. In addition, the BG/PAA composite maintained adequate residual compressive strength during the degradation period. The SEM results showed the differences in surface bioactivities of the composites directly, and 30BG/PAA composite showed thicker apatite layer and higher Ca/p than 15BG/PAA. in vitro MG-63 cell culture experiments showed that the composite was noncytotoxic and thus allows cells to adhere, proliferate, and differentiate. This indicates that the composite has good biocompatibility. The implantations in the bone defects of rabbits for 4 and 12 weeks were studied. The composites had good biocompatibility and were capable of guiding new bone formation without causing any inflammation. The composite may be successfully used in the development of bone implants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据