期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 76, 期 1, 页码 41-47出版社
IOS PRESS
DOI: 10.3233/JAD-200604
关键词
Alzheimer's disease; confinement; COVID-19; neuropsychiatric symptoms
资金
- Intramural Research Program of the National Institute on Aging, National Institutes of Health
- LABEX (excellence laboratory, program investment for the future) DISTALZ (Development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer Disease)
- EU CASCADE Interreg 2 Seas Programme 2014-2020 (European Regional Development Fund)
Background: Neuropsychiatric symptoms, such as depression, anxiety, apathy, agitation, and hallucinations, are frequent in Alzheimer's disease (AD) and their prevalence tends to increase with external stressors. Objective: We offer the first investigation of the effects of confinement during the COVID-19 crisis on neuropsychiatric symptoms in patients with AD. Methods: We contacted caregivers of 38 patients with AD who were confined to their homes for nearly two months and asked them to report whether patients experienced any change in neuropsychiatric symptoms during, compared to before, the confinement and rate its severity and impact on themselves using the Neuropsychiatric Inventory-Questionnaire. Results: Among the 38 patients, only 10 demonstrated neuropsychiatric changes during the confinement. Cognitive function of these 10 patients, assessed with the Mini-Mental State Examination, was worse than that of patients who did not demonstrate neuropsychiatric changes. Interestingly, among the 10 patients with neuropsychiatric changes, the duration of confinement significantly correlated with the severity of symptoms as well as with their caregivers' distress. Discussion: The confinement seems to impact neuropsychiatric symptomatology in AD patients with low baseline cognitive function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据