期刊
JACC-CARDIOVASCULAR INTERVENTIONS
卷 13, 期 11, 页码 1277-1287出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcin.2020.03.008
关键词
anesthesia; aortic stenosis; outcomes; TAVR; variation
OBJECTIVES The aims of this study were to examine variation in the use of conscious sedation (CS) for trans - catheter aortic valve replacement (TAVR) across hospitals and over time and to evaluate outcomes of CS compared with general anesthesia (GA) using instrumental variable analysis, a quasi -experimental method to control for unmeasured confounding. BACKGROUND Despite increasing use of CS for TAVR, contemporary data on utilization patterns are lacking, and existing studies evaluating the impact of sedation choice on outcomes may suffer from unmeasured confounding. METHODS Among 120,080 patients in the TVT (Transcatheter Valve Therapy) Registry who underwent transfemoral TAVR between January 2016 and March 2019, the relationship between anesthesia choice and TAVR out- comes was evaluated using hospital proportional use of CS as an instrumental variable. RESULTS Over the study period, the proportion of TAVR performed using CS increased from 33% to 64%, and CS was used in a median of 0% and 91% of cases in the lowest and highest quartiles of hospital CS use, respectively. On the basis of instrumental variable analysis, CS was associated with decreases in in -hospital mortality (adjusted risk difference: 0.2%; p 1 / 4 0.010) and 30 -day mortality (adjusted risk difference: 0.5%; p < 0.001), shorter length of hospital stay (adjusted difference: 0.8 days; p < 0.001), and more frequent discharge to home (adjusted risk difference: 2.8%; p < 0.001) compared with GA. The magnitude of bene fit for most endpoints was less than in a traditional propensity score -based approach, however. CONCLUSIONS In contemporary U.S. practice, the use of CS for TAVR continues to increase, although there remains wide variation across hospitals. The use of CS for TAVR is associated with improved outcomes (including reduced mortality) compared with GA, although the magnitude of bene fit appears to be less than in previous studies. (J Am Coll Cardiol Intv 2020;13:1277 -87) (c) 2020 by the American College of Cardiology Foundation.
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