Positively-charged electrosprayed nanoparticles based on biodegradable polymers containing amphotericin B for the treatment of leishmaniasis

Poly(epsilon-caprolactone) (PCL) electrosprayed nanoparticles (NPs) containing Amphotericin B (AMB) were prepared for the treatment of leishmaniasis. Two variations of PCL nanoparticles with positive surface charges, which can enhance cell uptake and restrict agglomeration, were produced: (1) NPs containing stearylamine and (2) core-shell nanoparticles, with chitosan in the shell and PCL and AMB in the core. The results proved the viability of producing positively charged PCL nanoparticles with AMB, with diameters <350 nm. The encapsulation efficiency of the drug was higher than 75%. The electrosprayed nanoparticles containing AMB were much less cytotoxic to cells than that of pure AMB. [GRAPHICS] .

Automated summary

The use of positively charged PCL nanoparticles to encapsulate AMB for the treatment of leishmaniasis is effective, as it can enhance drug encapsulation efficiency and reduce cytotoxicity to cells.