期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 70, 期 16, 页码 1189-1202出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2020.1785457
关键词
Amphotericin B; coaxial electrospraying; core-shell nanoparticles; leishmaniasis; nanoparticles; poly(epsilon-caprolactone)
资金
- CNPq
- FAPEMIG
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
The use of positively charged PCL nanoparticles to encapsulate AMB for the treatment of leishmaniasis is effective, as it can enhance drug encapsulation efficiency and reduce cytotoxicity to cells.
Poly(epsilon-caprolactone) (PCL) electrosprayed nanoparticles (NPs) containing Amphotericin B (AMB) were prepared for the treatment of leishmaniasis. Two variations of PCL nanoparticles with positive surface charges, which can enhance cell uptake and restrict agglomeration, were produced: (1) NPs containing stearylamine and (2) core-shell nanoparticles, with chitosan in the shell and PCL and AMB in the core. The results proved the viability of producing positively charged PCL nanoparticles with AMB, with diameters <350 nm. The encapsulation efficiency of the drug was higher than 75%. The electrosprayed nanoparticles containing AMB were much less cytotoxic to cells than that of pure AMB. [GRAPHICS] .
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