期刊
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
卷 25, 期 5, 页码 362-373出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1023666X.2020.1790253
关键词
Injectable hydrogel; poly(vinyl alcohol); bioactive glass; viscoelasticity; bone regeneration
资金
- Science and Technology Development Fund (STDF), Egypt [7982]
An injectable composite hydrogel composed of polyvinyl alcohol (PVA) and bioactive glass (BG) particles were synthesized by a physical crosslinking approach. The morphology, mechanical properties, and viscoelasticity of the PVA/BG composite hydrogel were characterized. Scanning electronic microscopy (SEM) showed uniform and homogeneous distribution of BG particles throughout the composite hydrogel. The incorporation of 2.5 wt% of BG particles in the composite hydrogel formulations, enhanced the static compressive strength and static elastic modulus by 325% and 150%, respectively. The storage molds (G ') was greater than the loss modules (G '') at all the frequency range studied, which revealed a self-standing elastic composite hydrogel with a smooth injectability. The PVA/BG composite hydrogel was also implanted subcutaneously in the dorsal region of adult male rats. After 4 weeks of implantation, no inflammatory cells were seen within and around the implant, which indicated that the composite hydrogel was biocompatible. The properties of the synthesized injectable PVA/BG composite hydrogel demonstrate its capability toward bone regeneration.
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