期刊
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
卷 25, 期 5, 页码 315-333出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1023666X.2020.1786271
关键词
Silk fibroin; chitosan; nanohydroxyapatite; blends; natural polymers
资金
- COST Action [MP [1301 EC]]
In this paper, a series of porous nanohydroxyapatite/silk fibroin/chitosan (nHA/SF/CTS) scaffolds were successfully prepared using the freeze-drying method. The biomaterials were characterized by attenuated total reflection Fourier transform infrared spectroscopy, and mechanical testing and thermogravimetric analysis. Moreover, studies of porosity, pore size, swelling properties and in vitro degradation test were performed. Research has proved that micro-structure, porosity, water adsorption and compressive strength were greatly affected by the components' concentration, in particular the content of silk fibroin. SEM observations showed that the scaffolds of nHA/SF/CTS are highly porous, with pore size in wide range from 25 to 300 mu m which is suitable for cell growth. nHA/SF/CTS scaffolds have sufficient mechanical integrity to resist handling during implantation andin vivoloading. Both, the compressive modulus and compressive strength of the scaffold, decrease with the increase in silk fibroin content.
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