期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 586, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119606
关键词
Cancer therapy; Molybdenum disulfide nanoflowers; Multimodal theranostics; Nanoenzyme; Transmembrane
资金
- National Natural Science Foundation of China [31922044, 81861138040, 81773280, 21675032]
- Natural Science Foundation of Shanghai [19ZR1471600]
- Fundamental Research Funds for the Central Universities
- DHU Distinguished Young Professor Program
- Minhang HospitalFudan Pharmacy Joint Project [RO-MY201802]
Developing an all-in-one multimodal theranostic platform that can synergistically integrate sensitive photoacoustic (PA) imaging, enhanced photothermal therapy (PTT) and photodynamic therapy (PDT) as well as the nano-enzyme activated chemodynamic therapy (CDT) presents a great challenge for the current nanomedicine design. Herein, a simple hydrothermal method was used to prepare porous molybdenum disulfide (MoS2) nanoflowers. These nanoflowers were assembled by three dimensional (3D)-stacked MoS2 nanosheets with plentiful pores and large surfaces, which thus exhibited enhanced photothermal conversion via light trapping and peroxidase (POD)-like activity via active defects exposure. Consequently, this 3D-MoS2 nanostructure could be well-sealed by polyethylene glycol-polyethylenimine polymer modified with nucleolar translocation signal sequence of the LIM Kinase 2 protein (LNP) via strong electrostatic interaction, which not only benefited to stably deliver anticancer drug doxorubicin (DOX) into the tumor cells for pH/NIR-responsive chemotherapy, but also provided strong photoacoustic, photothermal performances and stimulated generation of reactive oxygen species (ROS) for imaging-guided PTT/PDT/CDT combined therapy. This work promised a simple all-in-one multimodal theranostic platform to augment the potential antitumoral therapeutic outcomes.
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