期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 24, 期 1, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00405-16
关键词
immunization; low and middle-income countries; maternal; rotavirus
资金
- National Institute of Allergy and Infectious Diseases [R56AI108515, 5R01AI099601-05]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI108515, R01AI099601] Funding Source: NIH RePORTER
The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.
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