期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms21144869
关键词
neurogenesis; transcription factors; epigenetic modification; metabolism; p73; p53
资金
- Medical Research Council
- Associazione Italiana per la Ricerca contro il Cancro (AIRC) [20473, 23219]
- Ministry of Health
- MAECI Italy-China Science and Technology Cooperation [PGR00961]
- Regione Lazio through LazioInnova Progetto Gruppo di Ricerca [85-2017-14986]
- Children with Cancer UK fellowship [2014-178]
- Life Sciences Seed Fund-QMUL
- Bart Charity Grant [MGU0473]
Adult neurogenesis is a multistage process by which neurons are generated and integrated into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two specialized niches, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) adjacent to the lateral ventricles. Neurogenesis plays a fundamental role in postnatal brain, where it is required for neuronal plasticity. Moreover, perturbation of adult neurogenesis contributes to several human diseases, including cognitive impairment and neurodegenerative diseases. The interplay between extrinsic and intrinsic factors is fundamental in regulating neurogenesis. Over the past decades, several studies on intrinsic pathways, including transcription factors, have highlighted their fundamental role in regulating every stage of neurogenesis. However, it is likely that transcriptional regulation is part of a more sophisticated regulatory network, which includes epigenetic modifications, non-coding RNAs and metabolic pathways. Here, we review recent findings that advance our knowledge in epigenetic, transcriptional and metabolic regulation of adult neurogenesis in the SGZ of the hippocampus, with a special attention to the p53-family of transcription factors.
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