期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms21144852
关键词
WNT; beta-catenin; WNT5A; melanoma; immune evasion; signal transduction crosstalk
资金
- Medical University of Lodz [502-03/1-156-01/502-14-367, 503/1-156-01/503-11-001]
WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: beta-catenin-dependent signaling (canonical pathway) and beta-catenin-independent signaling (non-canonical pathway), the latter can be further divided into WNT/planar cell polarity (PCP) and calcium pathways. WNT ligands are considered as unique directional growth factors that contribute to both cell proliferation and polarity. Origin of cancer can be diverse and therefore tissue-specific differences can be found in WNT-signaling between cancers, including specific mutations contributing to cancer development. This review focuses on the role of the WNT-signaling pathway in melanoma. The current view on the role of WNT-signaling in cancer immunity as well as a short summary of WNT pathway-related drugs under investigation are also provided.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据