期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms21155203
关键词
fibrosis; innate immune cells; adaptive immune cells; myofibroblast; molecular mechanism
资金
- National Natural Science Foundation of China [91842304, 81771761]
- Health Research Fund from Yichang Science and Technology Bureau [A20-2-035]
- Hong Kong Health and Medical Research Fund [17160832]
- Hong Kong Croucher Foundation [260960116]
Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.
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