期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms21124489
关键词
mediterranean diet; fatty acid; omega-3; omega-6; omega-9; inflammation; malaria
资金
- Instituto Oswaldo Cruz
- Fundacao Oswaldo Cruz (FIOCRUZ)
- Coordenacao de Aperfeicoamento de Pessoal deNivel Superior (CAPES) [001]
- Programa de Neurociencias da Universidade Federal Fluminense (UFF)
- Universidade Federal do Estado do Rio de Janeiro (Unirio)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
The Mediterranean diet (MedDiet) consists of consumption of vegetables and healthy oils and have beneficial effects on metabolic and inflammatory diseases. Our goal here is to discuss the role of fatty acid content in MedDiet, mostly omega-3, omega-6, and omega-9 on malaria. Malaria affects millions of people around the globe. The parasite Plasmodium causes the disease. The metabolic and inflammatory alterations in the severe forms have damaging consequences to the host. The lipid content in the MedDiet holds anti-inflammatory and pro-resolutive features in the host and have detrimental effects on the Plasmodium. The lipids from the diet impact the balance of pro- and anti-inflammation, thus, lipids intake from the diet is critical to parasite elimination and host tissue damage caused by an immune response. Herein, we go into the cellular and molecular mechanisms and targets of the MedDiet fatty acids in the host and the parasite, reviewing potential benefits of the MedDiet, on inflammation, malaria infection progression, and clinical outcome.
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