期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms21155293
关键词
mast cells; breast cancer; tumor stroma; anti-tumor functions; IFN gamma
资金
- Fondo de Investigacion en Salud, Instituto Mexicano del Seguro Social (IMSS) [FIS/IMSS/PROT/G18/1829]
- Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico [CB2013-223678]
- Fondo de Apoyo a la Investigacion Hospital Infantil de Mexico Federico Gomez [HIM-2017-014]
Breast cancer (BrC) affects millions of women yearly. Mast cells (MCs) are common components of breast tumors with documented agonistic and antagonistic roles in tumor progression. Understanding the participation of MCs in BrC may lead to new therapies to control tumor growth. In this study, we looked into mechanistic models of MC responses triggered by BrC cells (BrCC), assessing both early degranulation and late transcriptional activities. We used aggressive and non-aggressive BrCC to model the progressive staging of the disease over HMC1 and LAD-2 human MC lines. We found that both MC lines were chemoattracted by all BrCC, but their activation was preferentially induced by aggressive lines, finding differences in their active transcriptional programs, both at basal level and after stimulation. Among those genes with altered expression were down-regulatedSPP1,PDCD1,IL17AandTGFB1and up-regulatedKITLGandIFNG. A low expression ofSPP1and a high expression ofKITLGandIFNGwere associated with increased overall survival of BrC patients from public databases. The set of altered genes is more often associated with tumor stromas enriched with anti-tumoral signals, suggesting that MCs may participate in tumor control.
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