期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms21124314
关键词
estrogen; estrogen receptors; estrogen receptor alpha; estrogen receptor beta; GPR30; hypertension; atherosclerosis; ischemia-reperfusion injury; heart failure with reduced ejection fraction; heart failure with preserved ejection fraction
资金
- National Institutes of Health [R01-HL131182]
Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17 million people die worldwide from CVD per year. There is considerable evidence suggesting that estrogen modulates cardiovascular physiology and function in both health and disease, and that it could potentially serve as a cardioprotective agent. The effects of estrogen on cardiovascular function are mediated by nuclear and membrane estrogen receptors (ERs), including estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta), and G-protein-coupled ER (GPR30 or GPER). Receptor binding in turn confers pleiotropic effects through both genomic and non-genomic signaling to maintain cardiovascular homeostasis. Each ER has been implicated in multiple pre-clinical cardiovascular disease models. This review will discuss current reports on the underlying molecular mechanisms of the ERs in regulating vascular pathology, with a special emphasis on hypertension, pulmonary hypertension, and atherosclerosis, as well as in regulating cardiac pathology, with a particular emphasis on ischemia/reperfusion injury, heart failure with reduced ejection fraction, and heart failure with preserved ejection fraction.
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