期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms21144884
关键词
antidepressant; treatment outcome; remission; improvement; genetic marker; whole-exome sequencing
资金
- National Research Foundation of Korea [NRF-2019M3C7A1031345]
- National Research Foundation of Korea [2019M3C7A1031345] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Planning subsequent treatment strategies based on early responses rather than waiting for delayed antidepressant action can be helpful. We identified genetic markers for later non-remission in patients exhibiting poor early improvement using whole-exome sequencing data of depressive patients treated in a naturalistic manner. Among 1000 patients, early improvement at 2 weeks (reduction in Hamilton Depression Rating Scale [HAM-D] score >= 20%) and remission at 12 weeks (HAM-D score <= 7) were evaluated. Gene- and variant-level analyses were conducted to compare patients who did not exhibit early improvement and did not eventually achieve remission (n= 126) with those who exhibited early improvement and achieved remission (n= 385). Genes predicting final non-remission in patients who exhibited poor early improvement (COMT, PRNP,BRPF3,SLC25A40,andCGREF1in males;PPFIBPI,LZTS3, MEPCE, MAP1A,andPFASin females;ST3GAL5in the total population) were determined. Among the significant genes, variants in thePRNP(rs1800014),COMT(rs6267),BRPF3(rs200565609), andSLC25A40genes (rs3213633) were identified. However, interpretations should be made cautiously, as complex pharmacotherapy involves various genes and pathways. Early detection of poor early improvement and final non-remission based on genetic risk would be helpful for decision-making in a clinical setting.
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