期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms21113858
关键词
SIRT1; NF-kappa B; inflammation; liver; NAFLD; cathepsins; AMPK; PPAR; NAD(+); STACs
资金
- Ministerio de Ciencia e Innovacion [RTI2018-095572-B-I00, RTI2018-095672-B-I00]
- Instituto de Salud Carlos III [PI19/01410]
- European Union (ERDF A way to make Europe)
Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause approximately 2 million deaths per year worldwide and hepatic inflammation is a common factor to all of them, being the main driver of hepatic tissue damage and causing progression from non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH), cirrhosis and, ultimately, hepatocellular carcinoma (HCC). The metabolic sensor SIRT1, a class III histone deacetylase with strong expression in metabolic tissues such as the liver, and transcription factor NF-kappa B, a master regulator of inflammatory response, show an antagonistic relationship in controlling inflammation. For this reason, SIRT1 targeting is emerging as a potential strategy to improve different metabolic and/or inflammatory pathologies. In this review, we explore diverse upstream regulators and some natural/synthetic activators of SIRT1 as possible therapeutic treatment for liver diseases.
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