期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms21113976
关键词
phytochemicals; gut microbiota; colon cancer stem cells; CRC therapy
资金
- Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, China [R201714, R201914]
Colorectal cancer (CRC) is a fatal disease caused by the uncontrolled propagation and endurance of atypical colon cells. A person's lifestyle and eating pattern have significant impacts on the CRC in a positive and/or negative way. Diet-derived phytochemicals modulate the microbiome as well as targeting colon cancer stem cells (CSCs) that are found to offer significant protective effects against CRC, which were organized in an appropriate spot on the paper. All information on dietary phytochemicals, gut microbiome, CSCs, and their influence on CRC were accessed from the various databases and electronic search engines. The effectiveness of CRC can be reduced using various dietary phytochemicals or modulating microbiome that reduces or inverses the progression of a tumor as well as CSCs, which could be a promising and efficient way to reduce the burden of CRC. Phytochemicals with modulation of gut microbiome continue to be auspicious investigations in CRC through noticeable anti-tumorigenic effects and goals to CSCs, which provides new openings for cancer inhibition and treatment.
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