相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions
Maria Szrejder et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)
Mechanism of glucose-lowering by metformin in type 2 diabetes: Role of bile acids
Daniel J. Sansome et al.
DIABETES OBESITY & METABOLISM (2020)
Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis
Jiang Xu et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)
Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2020
DIABETES CARE (2020)
The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease
Soie Kwon et al.
DIABETES CARE (2020)
The Prognosis of Patients With Type 2 Diabetes and Nonalbuminuric Diabetic Kidney Disease Is Not Always Poor: Implication of the Effects of Coexisting Macrovascular Complications (JDDM 54)
Hiroki Yokoyama et al.
DIABETES CARE (2020)
The importance of the initial period of basal insulin titration in people with diabetes
Milton Packer
DIABETES OBESITY & METABOLISM (2020)
Are the cardiovascular and kidney benefits of empagliflozin influenced by baseline glucose-lowering therapy?
Silvio E. Inzucchi et al.
DIABETES OBESITY & METABOLISM (2020)
Uric acid in CKD: has the jury come to the verdict?
Barbara Bonino et al.
JOURNAL OF NEPHROLOGY (2020)
Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway
Huiwen Ren et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)
GDF15 mediates the effects of metformin on body weight and energy balance
Anthony P. Coll et al.
NATURE (2020)
Innate immunity in diabetic kidney disease
Sydney C. W. Tang et al.
NATURE REVIEWS NEPHROLOGY (2020)
Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway
Xue Jiang et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)
Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis
Ganhua You et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2020)
Nonproteinuric diabetic kidney disease
Masayuki Yamanouchi et al.
CLINICAL AND EXPERIMENTAL NEPHROLOGY (2020)
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
Lucas Opazo-Rios et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis
Xu Jiang et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)
Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease
Cynthia M. Borges et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)
Metformin use and cardiovascular events in patients with type 2 diabetes and chronic kidney disease
David M. Charytan et al.
DIABETES OBESITY & METABOLISM (2019)
Hyperglycemia induces NF-κB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin
Zhanfang Kang et al.
CELL BIOLOGY INTERNATIONAL (2019)
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
V. Perkovic et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Unraveling the Role of Inflammation in the Pathogenesis of Diabetic Kidney Disease
Keiichiro Matoba et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Diabetic kidney disease: New clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on The natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function
Giuseppe Pugliese et al.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2019)
Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies
Guoqiang Zhang et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2019)
Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2
Michael Christensen et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2019)
Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity
Zydrune Polianskyte-Prause et al.
FASEB JOURNAL (2019)
Effect of sodium-glucose cotransporter 2 inhibitor, empagliflozin, and α-glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes
Ji-Won Kim et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Narrative review of the effects of antidiabetic drugs on albuminuria
Habib Yaribeygi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014
Shinji Kume et al.
JOURNAL OF DIABETES INVESTIGATION (2019)
Glomerular podocytes in diabetic renal disease
Pawel Podgorski et al.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2019)
ROCK2 regulates TGF-β-induced expression of CTGF and profibrotic genes via NF-κB and cytoskeleton dynamics in mesangial cells
Yosuke Nagai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)
Pathophysiological roles of nutrient-sensing mechanisms in diabetes and its complications
Shinji Kume
DIABETOLOGY INTERNATIONAL (2019)
The role of oxidative stress and hypoxia in renal disease
Tomoko Honda et al.
KIDNEY RESEARCH AND CLINICAL PRACTICE (2019)
Metformin modulates immune cell infiltration into the kidney during unilateral ureteral obstruction in mice
Michael Christensen et al.
PHYSIOLOGICAL REPORTS (2019)
Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease
Zachary A. Marcum et al.
JOURNAL OF GENERAL INTERNAL MEDICINE (2018)
Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK
Dorota Rogacka et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4
Jean-Daniel Lalau et al.
DIABETES CARE (2018)
Non-albuminuric renal impairment is a strong predictor of mortality in individuals with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicentre study
Giuseppe Penno et al.
DIABETOLOGIA (2018)
Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin
Mardiana Lee et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)
Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes A systematic review
Edith Pascale Mofo Mato et al.
MEDICINE (2018)
Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter
Hiroko Hashimoto et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2018)
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
Anila K. Madiraju et al.
NATURE MEDICINE (2018)
High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection
Hiroyuki Umino et al.
SCIENTIFIC REPORTS (2018)
Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes
Tongzhi Wu et al.
DIABETES OBESITY & METABOLISM (2017)
Nephroprotective Effects of Metformin in Diabetic Nephropathy
Sreenithya Ravindran et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Cellular senescence in renal ageing and disease
Ines Sturmlechner et al.
NATURE REVIEWS NEPHROLOGY (2017)
Metformin ameliorates podocyte damage by restoring renal tissue nephrin expression in type 2 diabetic rats
Limin Zhai et al.
JOURNAL OF DIABETES (2017)
SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy
Daiji Kawanami et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Metformin attenuates albumin-induced alterations in renal tubular cells in vitro
Soumaya Allouch et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu et al.
NATURE MEDICINE (2017)
DIABETES MELLITUS Complex interplay between metformin, AKI and lactic acidosis
Connie M. Rhee et al.
NATURE REVIEWS NEPHROLOGY (2017)
Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes
Siwei Zhang et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)
Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial
Kohjiro Ueki et al.
LANCET DIABETES & ENDOCRINOLOGY (2017)
Metformin: historical overview
Clifford J. Bailey
DIABETOLOGIA (2017)
Metformin attenuates renal fibrosis in both AMPKα2-dependent and independent manners
Yenan Feng et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2017)
Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism
Seung Hyeok Han et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
Simon A. Hawley et al.
DIABETES (2016)
Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014
Maryam Afkarian et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)
Unique features of long non-coding RNA biogenesis and function
Jeffrey J. Quinn et al.
NATURE REVIEWS GENETICS (2016)
Roles of mTOR complexes in the kidney: implications for renal disease and transplantation
Daniel Fantus et al.
NATURE REVIEWS NEPHROLOGY (2016)
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
Christoph Wanner et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney
Michael Christensen et al.
SCIENTIFIC REPORTS (2016)
Incretin-Based Therapies for Diabetic Complications: Basic Mechanisms and Clinical Evidence
Daiji Kawanami et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Metformin ameliorates lipotoxicity-induced mesangial cell apoptosis partly via upregulation of glucagon like peptide-1 receptor (GLP-1R)
Dong-il Kim et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2015)
Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy
C. Hu et al.
CURRENT MEDICINAL CHEMISTRY (2015)
Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study
Szu-Chun Hung et al.
LANCET DIABETES & ENDOCRINOLOGY (2015)
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
Hyun Mi Kang et al.
NATURE MEDICINE (2015)
Glomerular endothelial cell injury and cross talk in diabetic kidney disease
Jia Fu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)
Metformin: From Mechanisms of Action to Therapies
Marc Foretz et al.
CELL METABOLISM (2014)
Metformin in Patients With Type 2 Diabetes and Kidney Disease A Systematic Review
Silvio E. Inzucchi et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)
Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial
J. de Jager et al.
JOURNAL OF INTERNAL MEDICINE (2014)
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Anila K. Madiraju et al.
NATURE (2014)
The Effect of Novel Promoter Variants in MATE1 and MATE2 on the Pharmacokinetics and Pharmacodynamics of Metformin
S. L. Stocker et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Long-Term Outcomes of Japanese Type 2 Diabetic Patients With Biopsy-Proven Diabetic Nephropathy
Miho Shimizu et al.
DIABETES CARE (2013)
Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 Diabetes and Impaired Renal Function
Elif I. Ekinci et al.
DIABETES CARE (2013)
Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin
Junghyun Kim et al.
EXPERIMENTAL DIABETES RESEARCH (2012)
Metformin Inhibits Advanced Glycation End Products (AGEs)-induced Renal Tubular Cell Injury by Suppressing Reactive Oxygen Species Generation via Reducing Receptor for AGEs (RAGE) Expression
Y. Ishibashi et al.
HORMONE AND METABOLIC RESEARCH (2012)
Activation of AMP-Activated Protein Kinase Inhibits Albumin-Induced Endoplasmic Reticulum Stress and Apoptosis through Inhibition of Reactive Oxygen Species
Eun Kyoung Lee et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2012)
Beneficial effects of metformin and irbesartan on advanced glycation end products (AGEs)-RAGE-induced proximal tubular cell injury
Yuji Ishibashi et al.
PHARMACOLOGICAL RESEARCH (2012)
Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register
Nils Ekstrom et al.
BMJ OPEN (2012)
Renal Function in Type 2 Diabetes with Rosiglitazone, Metformin, and Glyburide Monotherapy
John M. Lachin et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin A Possible Role of HIF-1α Expression and Oxygen Metabolism
Yumi Takiyama et al.
DIABETES (2011)
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
X. Stephenne et al.
DIABETOLOGIA (2011)
Metformin Use and Mortality Among Patients With Diabetes and Atherothrombosis
Ronan Roussel et al.
ARCHIVES OF INTERNAL MEDICINE (2010)
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Marc Foretz et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Long-term Effects of Metformin on Metabolism and Microvascular and Macrovascular Disease in Patients With Type 2 Diabetes Mellitus
Adriaan Kooy et al.
ARCHIVES OF INTERNAL MEDICINE (2009)
Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study
Matth S. L. Becker et al.
DIABETES (2009)
Glucose, Metformin, and AICAR Regulate the Expression of G Protein-coupled Receptor Members in INS-1 β Cell
Q. R. Pan et al.
HORMONE AND METABOLIC RESEARCH (2009)
Albuminuria and Kidney Function Independently Predict Cardiovascular and Renal Outcomes in Diabetes
Toshiharu Ninomiya et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
10-year follow-up of intensive glucose control in type 2 diabetes
Rury R. Holman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
Yan Shu et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
Benoit Viollet et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
JM Lizcano et al.
EMBO JOURNAL (2004)
The short-term effect of a switch from glybenclamide to metformin on blood pressure and microalbuminuria in patients with type 2 diabetes mellitus
N Amador-Licona et al.
ARCHIVES OF MEDICAL RESEARCH (2000)