期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms21114189
关键词
cytokines; toll-like receptors; morbid obesity; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis
资金
- Brazilian National Research Council (CNPq)
- Ceara State Foundation for Scientific and Technological Development Support (FUNCAP)
- University ofModena and Reggio Emilia
- BPER Banca
The progression of nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) is linked to systemic inflammation. Currently, two of the aspects that need further investigation are diagnosis and treatment of NASH. In this sense, the aim of this study was to assess the relationship between circulating levels of cytokines, hepatic expression of toll-like receptors (TLRs), and degrees of NAFLD, and to investigate whether these levels could serve as noninvasive biomarkers of NASH. The present study assessed plasma levels of cytokines in 29 normal-weight women and 82 women with morbid obesity (MO) (subclassified: normal liver (n = 29), simple steatosis (n = 32), and NASH (n = 21)). We used enzyme-linked immunosorbent assays (ELISAs) to quantify cytokine and TLR4 levels and RTqPCR to assess TLRs hepatic expression. IL-1 beta, IL-8, IL-10, TNF-alpha, tPAI-1, and MCP-1 levels were increased, and adiponectin levels were decreased in women with MO. IL-8 was significantly higher in MO with NASH than in NL. To sum up, high levels of IL-8 were associated with the diagnosis of NASH in a cohort of women with morbid obesity. Moreover, a positive correlation between TLR2 hepatic expression and IL-8 circulating levels was found.
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