期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 46, 期 3, 页码 925-935出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2020.4662
关键词
myocardial reperfusion injury; neuregulin-1; protective agent; conditioning; receptor protein-tyrosine kinases; defense mechanism
资金
- Natural Science Foundation of Guangdong Province [2015A030310478, 2017A030313703]
As regards acute myocardial infarction, great success has been achieved in therapies that reduce the effects of myocardial ischemic injury, while few interventions have achieved satisfactory outcomes for myocardial ischemia-reperfusion (IR) injury. Thus, new research is urgently required to achieve breakthroughs in promising treatments. Neuregulin-1 (NRG-1), which is an endothelium-derived protein and the ligand of ErbB receptors, exerts cardioprotective effects and is rapidly upregulated during IR. NRG-1/ErbB activates several downstream signaling pathways in response to myocardial IR injury. Previous studies have revealed the protective effects of NRG-1 during heart failure, and numerous experiments have explored the mechanisms underlying the NRG-1-induced cardioprotective effects against myocardial IR injury. In the present review, the progress made in the research of NRG-1 as a cardioprotective agent during IR and related conditionings is summarized. Furthermore, the potential benefits of NRG-1 against myocardial IR injury are listed with the prospective use of NRG-1 in clinical applications.
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