期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 95, 期 -, 页码 204-209出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2020.04.018
关键词
KSHV prevalence; Transfusion-transmissible infections; Blood donors; Tanzania
资金
- US National Institute of Health (NIH)
- National Cancer Institute (NCI)
- Fogarty International Center (FIC) [1K43TW011418-01, U54 CA190155]
Objective: Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi's sarcoma (KS), one of the most common cancers in Tanzania. We have investigated KSHV prevalence and factors associated with KSHV infection in Tanzania. Methods: This is a cross-sectional study of voluntary blood-donors from Dar es Salaam, Tanzania. Plasma was screened for KSHV, HIV-1, HBV, HCV and Treponema pallidum (syphilis). Associations between KSHV sero-status and risk factors were analyzed. Odds ratios (OR) and 95% confidence intervals (CI) are reported to evaluate risk factors of KSHV infection. All tests were 2-tailed, and P-values <0.05 were considered statistically significant. Results: The overall KSHV seroprevalence was 56.9%. Significantly increased risk of KSHV infection was detected in persons from the Lake and Central Zones (OR = 6.4, 95% CI = 1.6-25.3, P = 0.008 and OR = 5.7, 95% CI = 1.0-32.5, P = 0.048 respectively). A trend toward increased risk of KSHV infection with HIV-1 co-infection was not significant (OR = 2.8, 95% CI = 1.0-8.0, P = 0.06). Seroreactivity to T. pallidum was surprisingly high (14.9%). Conclusion: The prevalence of KSHV infection and syphilis was high among Tanzanian blood-donors. The most common transfusion-transmissible infections did not associate with KSHV infection. Regions of focal KSHV infection need further investigation for underappreciated risk factors. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据