期刊
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
卷 45, 期 1, 页码 54-61出版社
WILEY
DOI: 10.1111/ceo.12872
关键词
Alzheimer disease; amyloid beta; biomarker; ocular; retina
资金
- Yulgilbar Alzheimer's Research Program
- Joan Margaret Ponting Charitable Trust
- University of Melbourne, Annemarie Mankiewicz-Zelkin Fellowship
- National Health and Medical Research Council Career Development Fellowship [1090466]
- Victorian Government
Interest in reliable biomarkers of Alzheimer disease, the leading cause of dementia, has been fuelled by challenges in diagnosing the disease and monitoring disease progression as well as the response to therapy. A range of ocular manifestations of Alzheimer disease, including retinal and lens amyloid-beta accumulation, retinal nerve fiber layer loss, and retinal vascular changes, have been proposed as potential biomarkers of the disease. Herein, we examine the evidence regarding the potential value of these ocular biomarkers of Alzheimer disease.
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