期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 162, 期 -, 页码 1888-1896出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.08.092
关键词
Hydrophobic alginate; Chitosan; Pickering emulsion; Drug release; Ibuprofen
资金
- Natural Science Foundation of Liaoning Province, China [201602185]
- Fundamental Research Funds for the Central Universities of Ministry of Education of China [DUT20LK43, DUT19TD33]
- Major National Scientific Instrument Development Project [21527812]
- MOST innovation team in key area [2016RA4053]
Alginate or chitosan microparticles as drug loading system performed pH-responsiveness and biocompatibility, yet with the burst-release and limited encapsulation. In order to improve the performance, herein, Pickering emulsion of chitosan-hydrophobic alginate nanocomposite (HSA-CS NCs) as the bio-stabilizer, was proposed as the drug-loading vehicle. Integrating the merits of HSA-CS and Pickering emulsion, such drug carrier of emulsion performed pH-response and biocompatibility from HSA-CS, and high loading capacity and rigid layer from Pickering emulsion, so as for the manipulated release behavior. With thorough investigation, via the various pH-response of HSA-CS nanocomposite in the continuous simulated gastrointestinal fluid, Pickering emulsion gradually released the loading drug (ibuprofen) out, performing the pH-triggered controlled-release behavior. Ibuprofen-loaded Pickering emulsions (30 mg/mL) released nearly none in SGF for 3 h, whereas in SIF, performed constant release in initial 5 h and continuous-release of 88.37% ibuprofen in 24 h with no drug-burst and high loading capacity, promisingly as the pH-responsive vehicle for drug delivery in oral route. (C) 2020 Elsevier B.V. All rights reserved.
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