期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 154, 期 -, 页码 835-843出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.03.161
关键词
Wound dressing; Chitosan; Cationicity; Hypertrophic scar
资金
- Key Research and Development Project of the 13th Five-Year Plan, China [2016YFC1101903]
- China Postdoctoral Science Foundation [2016M602690, 2018T110975]
- National Natural Science Foundation of China [81671826]
It is of great clinical significance to design wound dressing materials with combined excellent wound healing properties and superior capability to suppress hypertrophic scar formation. This study aimed to examine if and how the cationicity of chitosan would affect the hypertrophic scar-related outcomes, through preparing carboxymethyl chitosan hydrogels with different genipin concentrations (2.5%, 5%, 10% and 15%, respectively). An optimum window of chitosan cationicity (5% in our case) demonstrated potential to mitigate hypertrophic scar in wound healing by suppressing the expression of a-smooth muscle actin (a-SMA) and promoting secretion of type I matrix metalloproteinases (MMP-1). In vivo, the CMCS-5% hydrogel again showed smaller, thinner and smoother wound appearance. Moreover, the CMCS-5% sample with additional incorporation of 2% (V/V) Aloe vera gel exhibited further improved performance in scar inhibition. Overall, such findings might have important implications in chitosan-based wound dressing design for high-quality wound repair and effective scar inhibition. (C) 2020 Elsevier B.V. All rights reserved.
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