期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 83, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2020.106426
关键词
Andrographolide sulfonate; TNBS; Chronic colitis; Fibrosis
资金
- National Natural Science Foundation of China [81922067, 81730100, 81903620]
- Natural Science Foundation of Jiangsu Province [BK20190306]
- Open Fund of State Key Laboratory of Innovative Natural Medicine and TCM Injections [QFSKL2018008]
- Zhejiang University special scientific research fund for COVID-19 prevention and control [2020XGZX007]
Inflammatory bowel disease could result in diarrhea and abdominal pain, as well as potential complications such as tissue fibrosis. The therapeutic effect of andrographolide sulfonate on acute murine experimental colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) has been confirmed. In the study here, chronic colitis triggered by repeated intrarectal administration of TNBS was established and the effect of andrographolide sulfonate was examined. Repeated TNBS administration induced substantial mice death, which was significantly decreased by andrographolide sulfonate treatment. The elevation of inflammatory cytokines including IL-6, IL-17A, TNF-alpha as well as IFN-gamma in colonic tissues levels were decreased after administration of andrographolide sulfonate. Next, CD4(+) T cell and macrophage infiltration was found to descend. The subset of pathogenic CD4(+) T cell subset including CD4(+)IFN-gamma(+) (Th1) and CD4(+)IL-17A(+) (Th17) were also suppressed by andrographolide sulfonate. Further, the restrain of p38 and p65 activation were also observed after andrographolide sulfonate administration. Finally, TNBS-induced colonic epithelial damage as well as fibrosis were significantly mitigated by andrographolide sulfonate. Based on the results got here, we can make a conclusion that andrographolide sulfonate could decrease inflammation and epithelial damage as well as fibrosis thus ameliorating chronic colitis in mice. Our study suggest the possible use of andrographolide sulfonate for chronic colitis treatment in clinical.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据