期刊
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
卷 59, 期 39, 页码 17147-17155出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.iecr.0c01279
关键词
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资金
- National Natural Science Foundation of China [21808069, 21878103, 21676098]
- Natural Science Foundation of Guangdong Province of China [2018A030310368]
- Science and Technology Planning Project of Guangdong Province of China [2019A050510008]
Clostridium tyrobutyricum ATCC 25755 is a promising butyric acid-producing strain. However, the existence of acetic acid as a byproduct decreases butyric acid yield and increases downstream processing cost. In this study, we demonstrated that mannitol/glucose cofermentation with appropriate ratio (1:2 or 2:3) achieved high butyric acid yield (0.44-0.45 g/g) and selectivity (100%). To further improve the economic viability of butyric acid fermentation, we selected Saccharina japonica as a potential source of mannitol. The optimum condition (10% seaweed biomass in 0.11 M H2SO4 at 120 degrees C for 31 min) for mannitol release was identified through response surface methodology (RSM). After acid hydrolysis and enzyme saccharification, the feasibility of high-selectivity butyric acid production from S. japonica hydrolysate (supplemented with glucose to achieve a mannitol/glucose ratio of 1:2 and replaced (NH4)(2)SO4 with NH4Ac) was verified in the bioreactor, providing a promising approach for cost-effective production of biobased butyric acid.
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