期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 40, 期 3, 页码 499-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2020.03.005
关键词
Specific antibody deficiency; Antibody deficiency; Diagnosis; Immunoglobulin replacement therapy; Pneumococcal vaccines; PCV13; PPSV23; Primary immunodeficiency
Specific antibody deficiency is a primary immunodeficiency disease recognized by the International Union of Immunology Societies and defined by recurrent respiratory infections with normal immunoglobulins, but diminished antibody responses to polysaccharide antigens after vaccination with the 23 valent pneumococcal polysaccharide vaccine. Clinical immunologists struggle with diagnosis and treatment, because the definition of an adequate response to immunization remains controversial. Specific antibody deficiency is managed clinically with close follow-up and prompt treatment of infections, antibiotic prophylaxis, or immune globulin therapy. Treatment is individualized using clinical judgment and existing practice guidelines, which will likely evolve as more studies become available.
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