期刊
IMMUNOLOGICAL REVIEWS
卷 298, 期 1, 页码 10-24出版社
WILEY
DOI: 10.1111/imr.12905
关键词
host defense; IL-17; IL-22; thymic development; type 17 cytokines; type 3 immunity; gamma delta T cell memory; gamma delta T cells; gamma delta T-17 cells
类别
The gamma delta T cells play an important role in both mice and humans as a source of the cytokine IL-17, which is key for immune resistance to certain pathogens. In mice, most of these IL-17 producers, termed gamma delta T-17 cells, actually comprise two distinct types: those expressing an invariant V gamma 6V delta 1(+)TCR and those expressing a V gamma 4(+)TCR. Murine gamma delta T-17 cells acquire an inherent bias to produce IL-17 and other type 17 cytokines during thymic development. The similarities and differences between the two mouse gamma delta T-17 types are reviewed here, and the potential implications of their differences are discussed. There is some evidence that two distinct TCR-defined IL-17-producing gamma delta T cell subsets also exist in humans, but unlike the mouse gamma delta T-17 cells, these cells are probably not imprinted with an IL-17 bias during thymic development, but rather acquire an IL-17 bias in the periphery.
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