期刊
CLINICA CHIMICA ACTA
卷 463, 期 -, 页码 53-61出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2016.10.005
关键词
metabolic markers; mass spectrometry; prediabetes; obesity; observational study
资金
- Juan de la Cierva fellowship [MINECO]
- [Plan N de I + D + i] - ISCII-Subdireccion General de Evaluacion y Fomento de la Investigacion [PI13/01172]
- Fondo Europeo de Desarrollo Regional (FEDER)
- Fundacion Progreso y Salud [PI-0557-2013]
- Consejeria de Salud y Bienestar Social
- Junta de Andalucia
- FEDER
- Generalitat de Catalunya's Agency AGAUR [2014SGR1566]
- ISCIII-CIBEROBN
Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R = -0.56, p = 0.0003; lysoPC C18:1: R = -0.61, p = 0.0001; lysoPC C18:2 R = -0.64, p < 0.0001] Several amino acids were biomarkers of risk of diabetes onset associated to obesity. For instance, glutamate significantly associated with fasting insulin [R = 0.5,p = 0.0019] and HOMA-IR [R = 0.46,p = 0.0072], while glycine showed negative associations [fasting insulin: R = -0.51, p = 0.0017; HOMA-IR: R = -0.49, p = 0.0033], and the branched chain amino acid valine associated to prediabetes and insulin resistance in a BMI-independent manner [fasting insulin: R = 0.37,p = 0.0479; HOMA-IR: R = 0.37,p = 0.0468]. Minority sphingolipids including specific [dihydro]ceramides and sphingomyelins also associated with the prediabetic insulin resistant state, hence deserving attention as potential targets for early diagnosis or therapeutic intervention. (C) 2016 Elsevier B.V. All rights reserved.
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