期刊
CLINICA CHIMICA ACTA
卷 455, 期 -, 页码 26-32出版社
ELSEVIER
DOI: 10.1016/j.cca.2016.01.016
关键词
Colorectal cancer; Blood-based biomarkers; Liquid biopsy; Circulating tumor cells; Cell-free DNA; DNA methylation; Point mutations; Histone methylation
The global burden of colorectal cancer (CRC)-associated morbidity and mortality is-increasing, in part due to a lack of early detection. Direct structural examination techniques, such as colonoscopy, are invasive and can therefore affect the willingness of patients to participate in screening. Recently, the use of liquid biopsy has gained considerable attention as a novel source of biomarkers. Blood-based biomarkers could prove to be practical tools for CRC detection, as the monitoring of biomarkers in biological fluids offers many advantages, including minimal invasiveness and easy accessibility. Biomarkers with high specificity and sensitivity can enable the detection of CRC at an early stage, thereby improving prognosis, prediction of treatment response, and recurrence risk. In this review, we summarize that the biomarkers currently thought to have potential for the early detection and monitoring of CRC, including circulating tumor cells, DNA, RNA and proteins. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据