期刊
CLINICA CHIMICA ACTA
卷 462, 期 -, 页码 193-200出版社
ELSEVIER
DOI: 10.1016/j.cca.2016.09.020
关键词
Lipids; Lipoproteins; Apolipoproteins; High-sensitivity C-reactive protein; High-sensitivity cardiac troponin; 99th percentile URL
资金
- Collegium Medicum of Nicolaus Copernicus University (NCU CM) [779/2014]
Objectives: i) To assess the relationship between lipid markers and high-sensitivity C-reactive protein (hs-CRP), and high-sensitivity cardiac troponin I (hs-cTnI) in the reference population, and ii) to evaluate the impact of lipid markers and hs-CRP on the 99th percentile upper reference limit (URL) for hs-cTnI. Methods: 531 questionnaire-identified presumably healthy individuals were enrolled in a single-center, cross-sectional study. Surrogate biomarkers for diabetes, myocardial and renal dysfunction were used to refine the healthy cohort (n = 408). Lipid profile, total cholesterol:high-density lipoprotein cholesterol (HDL-C) ratio, non-HDL-C, apolipoprotein AI (apoAI), apolipoprotein B (apoB), apoB:apoAl ratio, lipoprotein(a), small dense low-density lipoprotein cholesterol (LDL-C) and hs-CRP were determined. Results: Individuals with detectable vs. non-detectable hs-cTnI concentrations more often showed elevated LDL-C (60% vs. 46%; p = 0.002), apoB (73% vs. 61%; p = 0.008), apoB:apoAl ratio (53% vs. 40%; p = 0.005) and lipoprotein(a) (15% vs. 7%; p = 0.015). The apoB:apoAl ratio and to a lesser extent other lipid markers, but not hs-CRP, were positively associated with hs-cTnI concentration in univariate and multivariate analyses. Exclusion of individuals with elevated apoB:apoAl ratio or apoB, but not hs-CRP, lowered the 99th percentile URL in the healthy cohort respectively by 12.9% (6.2 vs. 5.4 ng/L) and 14.5% (6.2 vs. 53 ng/L). The corresponding reduction for both lipid biomarkers in the presumably healthy population was 24.0% (7.5 vs. 5.7 ng/L). Conclusion: Our study demonstrates that atherogenic lipid markers, particularly apoB:apoAl ratio or apoB, influence the 99th percentile URL for hs-cTnl. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据