期刊
CLINICA CHIMICA ACTA
卷 460, 期 -, 页码 164-171出版社
ELSEVIER
DOI: 10.1016/j.cca.2016.06.044
关键词
Atherosclerosis; microRNA; Endothelial cells; Vascular smooth muscle cells; Macrophages; Inflammation
资金
- National Natural Science Foundation of China [81200217, 81370376]
- Natural Science Foundation of Hunan Province [2015JJ4097]
- Key Project of Science and Technology Department of Hunan Province [2015JC3081]
- Key Project of the Education Department of Hunan Province [15A137]
- Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education [CQKLBST-2014-002, CQKLBST-2015-004]
- Construct Program of the Key Discipline in Hunan Province [[2011] 76]
MicroRNAs are a group of endogenously small non-coding RNA molecules that downregulate gene expression at the post-transcriptional level through binding to the 3'UTR of target mRNAs. Recent findings have revealed a key role for microRNAs in the pathophysiological processes of atherosclerosis. As a complex disease, atherosclerosis is influenced by a combination of multiple genes and environmental factors. Both of them play a role in atherogenesis by affecting different types of cells (such as endothelial cell, vascular smooth muscle cell and monocyte/macrophage) function. MicroRNAs control the senescence and dysfunction of endothelial cells, proliferation and migration of vascular smooth muscle cells, and macrophage-driven cytokine production and polarization. By these effects, microRNAs can influence the processes of atherosclerosis and may represent new molecular targets for therapy. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据