期刊
CLINICA CHIMICA ACTA
卷 453, 期 -, 页码 21-27出版社
ELSEVIER
DOI: 10.1016/j.cca.2015.11.027
关键词
High-sensitivity C-reactive protein; Hemorrhagic stroke; lschemic stroke; Meta-analysis; Stroke
资金
- Key R & D special fund of Jiangsu Province [BE2015666]
Background: Studies on high-sensitivity C-reactive protein (hs-CRP) and stroke risk have yielded conflicting results. Objective: To determine whether elevated baseline hs-CRP presents an independent risk for different kinds of strokes by conducting a meta-analysis. Methods: The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure and Wanfang databases were systematically searched for prospective observational studies published until January 2015. Studies reporting hs-CRP levels and adjusted risk estimates of different stroke subtypes by hs-CRP were selected. Pooled results were expressed as adjusted risk ratios (RRs), with corresponding 95% confidence intervals (CI) for the highest versus the lowest hs-CRP category. Results: Twelve studies involving 2269 strokes, of which 2436 were ischemic and 655 were hemorrhagic, were identified from 66,560 participants. When comparing the highest with the lowest hs-CRP category, the pooled RR of ischemic strokes was 1.46 (95% CI 1.27-1.67) in a fixed-effect model. The pooled RRs of all strokes and hemorrhagic stroke were 1.23 (95% CI: 0.997-1.51) and 0.82 (95% CI 0.59-1.13), respectively. The risk of ischemic strokes seemed higher in men (RR 1.66; 95% CI 123-2.24). Conclusions: Elevated baseline hs-CRP levels are independently associated with excessive ischemic stroke risk but exhibit no clear effect on hemorrhagic stroke. (C) 2015 Elsevier B.V. All rights reserved.
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