期刊
HUMAN BRAIN MAPPING
卷 43, 期 1, 页码 255-277出版社
WILEY
DOI: 10.1002/hbm.25096
关键词
data sharing; generalized anxiety disorder; mega-analyses; meta-analyses; neuroimaging
资金
- Fondazione Cariplo [2016-0908]
- Hartford HealthCare Research Funding Initiative [129522]
- Federal Ministry of Education and Research [01ZZ0403, 01ZZ0103, 01ZZ9603, 01ER1703, 01ER1303]
- National Institutes of Health (NIH) [K23MH109983, T32MH100019, R01MH101486, U54-EB020403, ZIA-MH002782, ZIA-MH002781]
The ENIGMA-Anxiety/GAD group is conducting a mega-analysis of brain structural scans for generalized anxiety disorder. This report summarizes the challenges faced and the approach taken to overcome them, aiming to guide other research groups working with large brain imaging data sets.
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.
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