期刊
HEPATOLOGY RESEARCH
卷 50, 期 9, 页码 1015-1023出版社
WILEY
DOI: 10.1111/hepr.13540
关键词
acute fatty liver of pregnancy; hemolysis; elevated liver enzymes; and a low platelet counts syndrome; intrahepatic cholestasis of pregnancy; non-alcoholic fatty liver disease; pregnancy; pregnancy outcome
资金
- Health and Labor Sciences Research Grant Funding Source: Medline
Development of liver diseases during pregnancy is not uncommon. They are caused by either a disorder that is unique to pregnancy or an acute or chronic liver disease that already exists or coincidentally develops as a comorbidity of pregnancy. Liver diseases unique to pregnancy include hyperemesis gravidarum; hypertensive disorders of pregnancy, such as pre-eclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelet count syndrome; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Chronic liver diseases that affect pregnancy, or are affected by pregnancy, mainly include autoimmune liver diseases and non-alcoholic fatty liver disease. Prompt diagnosis and management of liver diseases in pregnancy, while very challenging, is extremely important, as they might cause adverse maternal and fetal outcomes. Therefore, a multidisciplinary, collaborative approach involving both hepatologists and obstetricians is required. In this review article, the up-to-date epidemiology, etiology, clinical features, and outcomes of liver diseases in pregnancy are discussed, to promote a deeper understanding among physicians, and subsequently improved outcomes.
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