期刊
HEART AND VESSELS
卷 36, 期 1, 页码 38-47出版社
SPRINGER
DOI: 10.1007/s00380-020-01663-4
关键词
8-Hydroxydeoxyguanosine; Oxidative stress; Acute coronary syndrome
资金
- Astellas
- Astra Zeneca
- Daiichi Sankyo
- Boehringer Ingelheim
- Eisai
- Kowa
- Kyowa Hakko Kirin
- Merck
- Mitsubishi Tanabe
- Ono
- Otsuka
- Pfizer
- Sanofi Aventis
- Shionogi
- Sumitomo Dainippon
- Takeda
- Terumo
High admission urinary 8-OhdG levels independently predict cardiovascular mortality and major cardiovascular events in patients with ACS.
The aim of the present study was to determine whether urinary 8-hydroxydeoxyguanosine (8-OHdG), which is a marker of oxidative stress, can predict future cardiovascular death in patients with acute coronary syndrome (ACS). A total of 551 consecutive patients with ACS who underwent admission urinary 8-OHdG measurements were enrolled in this study. The patients were divided into 2 groups according to the optimal cutoff value of admission urinary 8-OHdG determined by a receiver-operating characteristics curve for the prediction of cardiovascular death: a high admission urinary 8-OHdG group, 169 patients with admission urinary 8-OHdG >= 17.92 ng/mg creatinine; and a low admission urinary 8-OHdG group, 382 patients with admission urinary 8-OHdG < 17.92 ng/mg creatinine. The patients were followed up for a median period of 34 months. The primary and secondary end points were the incidence of cardiovascular death and major cardiovascular events (MACE) composed of cardiovascular death, non-fatal myocardial infarction, or urgent hospitalization for heart failure. Of the 551 patients, cardiovascular deaths and MACE occurred in 14 (2.5%) and 35 (6.4%), respectively. The Kaplan-Meier estimate of the event-free rate revealed cardiovascular deaths and MACE were more likely in the high admission 8-OHdG group than in the low admission 8-OHdG group (log rank, bothP < 0.001). Multiple adjusted Cox proportional hazards analysis indicated that high admission urinary 8-OHdG was an independent predictor of cardiovascular death (hazard ratio [HR] 7.642,P = 0.011) and MACE (HR 2.153,P = 0.049). High admission urinary 8-OHdG levels predict cardiovascular mortality after adjustment in patients with ACS.
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