Elevation of progesterone on the trigger day exerts no carryover effect on live birth in freeze-all cycles

Aim:To evaluate the effect of trigger day progesterone (P) levels on live birth in freeze-all cycles. Material and methods:Retrospective analysis of 1034 freeze-all female patients aged <38 years with single blastocyst transfers. Patients with (n = 268) or without (n = 766) preimplantation genetic test for aneuploidy (PGT-A) arm were further categorized into three subgroups based on trigger day P levels; low (<0.80 ng/ml), medium (0.8-1.49 ng/ml), and high (>= 1.50 ng/ml). Results:Estradiol (E2) levels on trigger day, the number of oocytes retrieved and the number of mature oocytes increased significantly with increasing serumpvalues in cycles without and with PGT-A arms. Significant correlation was found between E2 levels on trigger day and serum P levels and between the number of total oocytes retrieved and serum P levels Live birth rates were similar in the three subgroups in without PGT-A arm (51%, 52.6%, and 51.5%, respectively;p = .922) and with PGT-A arm (55.1%, 55.1%, and 62.5%, respectively;p = .730). Multivariate regression analysis revealed that trigger day P levels were not significant for live birth. Conclusion:The proposal that trigger day progesterone elevation (PE) exerts a detrimental effect on oocyte and embryo competence has no clinical validity. Keywords:Freeze-all; IVF/ICSI; trigger day progesterone

Automated summary

The trigger day progesterone levels do not significantly affect live birth rates in frozen embryo transfer cycles, suggesting that the elevation of progesterone on trigger day may not have a detrimental effect on oocyte and embryo competence.