期刊
GERONTOLOGY
卷 66, 期 5, 页码 419-426出版社
KARGER
DOI: 10.1159/000508459
关键词
Lymphatic vessels; Aging; Atherosclerosis; Endothelial cells
资金
- Austrian National Bank [15953]
- Science Fund of the State of Tyrol [UNI-0404/1395]
- Lore-and-Udo Saldow Donation
The lymphatic system is responsible for fluid drainage from almost every organ in the body. It sustains tissue homeostasis and is also a central part of the immune system. With the discovery of cell-specific markers and transgenic mouse models, it has become possible to gain some insight into the developmental and functional roles of lymphatic endothelial cells (LECs). Only recently, a more direct regulatory role has been assigned to LECs in their functions in immunity responses and chronic diseases. Here, we discuss the changes occurring in aged lymphatic system and the role of lymphatic capillaries in some age-related diseases and experimental animal models.(c) 2020 The Author(s) Published by S. Karger AG, Basel
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