期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 58, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2020.100852
关键词
Pituitary neuroendocrine tumour; Tumour microenvironment; Immune cell; Stromal cell; Cytokine; Chemokine; Growth factor; Extracellular matrix; Epithelial-to-mesenchymal transition
资金
- Barts and the London Charity
- Joan Adams Fellowship
- Medical Research Council
- Rosetrees Trust
The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is known in pituitary tumours. However, the understanding of the TME of pituitary tumours has advanced thanks to active research in this field over the last decade. Different immune and stromal cell subpopulations, and several cytokines, growth factors and matrix remodelling enzymes, have been characterised in pituitary tumours. Studying the TME in pituitary tumours may lead to a better understanding of tumourigenic mechanisms, identification of biomarkers useful to predict aggressive disease, and development of novel therapies. This review summarises the current knowledge on the different TME cellular/non-cellular elements in pituitary tumours and provides an overview of their role in tumourigenesis, biological behaviour and clinical outcomes.
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