期刊
FOOD CHEMISTRY
卷 315, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2020.126266
关键词
Flaxseed; Polysaccharide; Immune-enhancing; MAPK
资金
- National Key Research and Development Program of China [2017YFD0401301]
- National Natural Science Foundation of China [31901699]
- Jiangsu Agriculture Science and Technology Innovation Fund (JASTIF) [CX(18) 3039]
- Open Project Program of Guandong Provincial Key Laboratory of Nutraceuticals and Functional Foods
- Jiangsu Planned Projects for Postdoctoral Research Funds
Flaxseeds are widely consumed for their desirable sensory attributes and health benefits. We focused on enhancing the sustainability and economic potential of flaxseeds by characterizing functional attributes of polysaccharides isolated from flaxseed hull residues. In particular, antioxidant and immune-stimulatory polysaccharides were isolated and purified from flaxseed hull. Infrared spectroscopy was used to identify the key functional groups. The polysaccharides were composed of mannose, rhamnose, galactose, glucose, galactose, xylose, arabinose, and fucose. In vitro studies showed certain flaxseed hull polysaccharide fractions exhibited strong antioxidant activities, increased nitric oxide levels, and enhanced the production of cytokines (TNF-alpha and IL-6). In the presence of 200 mu g/mL of one of these fractions, the levels of p-ERK, p-JNK, and p-p38 increased significantly by 1.8-, 9.0-, and 6.7-fold. These polysaccharide fractions may exhibit their immune-regulatory properties partly by modulating the MAPK pathway. The flaxseed hull polysaccharides identified have potential application as natural antioxidants and immune-enhancing nutraceuticals.
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