期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 141, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2020.111373
关键词
DON; Weaning pigs; Growth retardation; Gut health; Microbiome; Adsorbent
资金
- National Key Research and Development Program of China [2016YFD0501207, 2018YFD0500601]
- Innovation Group of Hubei Natural Science Foundation [2018CFA020]
The objectives of this study were to determine the effects of deoxynivalenol (DON) on growth performance and intestinal microbiota in weaning piglets, and potential efficacy of a modified hydrated sodium calcium aluminosilicate (HSCAS) adsorbent to reduce DON toxicity. Four groups of 21-day-old male piglets (n = 7/group) were fed either a control diet, or diet containing 1.0 or 3.0 mg/kg DON, or 3.0 mg/kg DON plus 0.05% modified HSCAS for 28 d. Compared to the control, dietary DON at 1.0 and/or 3.0 mg/kg reduced (P < 0.05) the body weight gain (16.0-60.8%) and feed intake (18.1-38.7%) during the whole experiment, and increased (P < 0.05) the feed/gain ratio (12.8-33.8%) between d 1-28. The body weight gain and feed intake were further decreased (P < 0.05) in 3.0 mg/kg DON in comparison to 1.0 mg/kg DON during d 15-28. DON exposure reshaped gut microbial structure by drastically affecting the abundance of several bacterial phyla, families and genera, including dysbiosis of Actinobacteria, Cyanobacteria, Firmicutes, and Proteobacteria in small intestine. Notably, dietary Amdetox (TM) supplementation alleviated the adverse effects of DON on growth performance of piglets and improved the intestinal flora disorder. Therefore, the current study has revealed that Amdetox (TM) , the modified HSCAS binder, can alleviate DON-induced negative effects and could be used as a promising countermeasure for reducing DON toxicity.
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