期刊
FITOTERAPIA
卷 143, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2020.104571
关键词
Terminalia chebula var. tomentella; Combretaceae; Lignans; Calculated ECD; Anti-inflammatory activity
资金
- Key Project of Basic Research Plan of Yunnan Province [2020FA018?]
- Yunnan Key Laboratory of Natural Medicinal Chemistry [S2017-ZZ14]
An elaborated phytochemical study on the fresh fruits of Terminalia chebula var. tomentella (Combretaceae) led to the isolation of five new lignans, including three tetrahydrofuran (1-3) and two furofuran (4 and 5) derivatives, namely termitomenins A-E (1-5), along with 10 known ones. All of them were obtained from the titled plant for the first time. Their structures were determined by extensive spectroscopic analysis, including 1D/2D NMR, MS, UV, IR, electronic circular dichroism (ECD), time-dependent density functional theory (TDDFT) calculation of ECD spectra, and single crystal X-ray diffraction in case of 3. Compounds 1-15 exhibited certain anti-inflammatory activities. Interestingly, compounds 6 (IC50 = 18.17 +/- 0.57 mu M) and 7 (IC50 = 13.66 +/- 0.38 mu M) which contain an aldehyde group displayed stronger NO inhibitory activity than the positive control L-NMMA (IC50 = 42.34 +/- 0.66 mu M).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据