期刊
FERTILITY AND STERILITY
卷 114, 期 3, 页码 465-474出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2020.06.038
关键词
Kisspeptins; Gpr54; GnRH; gonadotropins; ovulation
资金
- Ministerio de Economia y Competitividad, Spain [BFU2014-57581-P, BFU2017-83934-P]
- E.U. funds from the FEDER Program
- Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain [PIE14-00005]
- E.U. research contract DEER [FP7-ENV-2007-1]
- Finnish Distinguished Professor Program of the Academy of Finland
In humans and other mammals, a hallmark of female reproductive function is the capacity to episodically release fertilizable oocytes under the precise control of a cascade of hormonal regulators that interplay in a cyclic manner within the hypothalamic-pituitary-ovarian (HPO) axis. Although the basic elements of this neurohormonal system were disclosed several decades before, a major breakthrough in our understanding of how the HPO axis is controlled during the lifespan came in the first decade of the 21st century, when the reproductive dimension of kisspeptins was disclosed by seminal studies documenting that genetic inactivation of the kisspeptin pathway is linked to central hypogonadism and infertility. Kisspeptins are a family of peptides, encoded by the Kiss1 gene, that operate via the surface receptor, Gpr54 (also called Kiss1r), to regulate virtually all aspects of reproduction in both sexes. The primary site of action of kisspeptins is the hypothalamus, where Kiss1 neurons engage in the precise control of the pulsatile release of GnRH to modulate gonadotropin secretion and, thereby, ovarian function. Nonetheless, additional sites of action of kisspept ins within the HPO axis, including the pituitary and the ovary, have been proposed; yet, the physiologic relevance of such extrahypothalamic actions of kisspeptins is still a matter of debate. In this review, we summarize the current consensus knowledge and open questions on the sites of action, physiologic roles, and eventual therapeutic implications of kisspeptins in the control of the female reproductive axis. (C) 2020 by American Society for Reproductive Medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据