期刊
FEMS YEAST RESEARCH
卷 20, 期 6, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsyr/foaa037
关键词
mitochondria; metabolic engineering; mitochondrial engineering; metabolism; chemical production; biotechnology
资金
- United States Department of Energy, Office of Science, Office of Biological and Environmental Research, Genomic Science Program [DESC0019363]
- National Science Foundation CAREER Award [CBET-1751840]
- Pew Charitable Trusts
- Camille and Henry Dreyfus Foundation
The mitochondria, often referred to as the powerhouse of the cell, offer a unique physicochemical environment enriched with a distinct set of enzymes, metabolites and cofactors ready to be exploited for metabolic engineering. In this review, we discuss how the mitochondrion has been engineered in the traditional sense of metabolic engineering or completely bypassed for chemical production. We then describe the more recent approach of harnessing the mitochondria to compartmentalize engineered metabolic pathways, including for the production of alcohols, terpenoids, sterols, organic acids and other valuable products. We explain the different mechanisms by which mitochondrial compartmentalization benefits engineered metabolic pathways to boost chemical production. Finally, we discuss the key challenges that need to be overcome to expand the applicability of mitochondrial engineering and reach the full potential of this emerging field.
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