期刊
FEBS JOURNAL
卷 288, 期 5, 页码 1434-1446出版社
WILEY
DOI: 10.1111/febs.15484
关键词
actin-bundling; cancer metastasis; fascin; metastatic colonization
资金
- NIH [R01 CA 233844]
- Penn State Cancer Institute
- Elsa U. Pardee Foundation
Fascin is an F-actin-bundling protein associated with poor prognosis and metastatic progression in cancer. It plays a crucial role in cancer metastasis, and understanding its mechanisms is essential for developing anti-metastasis therapeutics targeting Fascin.
Fascin is an F-actin-bundling protein that cross-links individual actin filaments into straight and stiff bundles. Fascin overexpression in cancer is strongly associated with poor prognosis and metastatic progression across different cancer types. It is well established that fascin plays a causative role in promoting metastatic progression. We will review the recent progress in our understanding of mechanisms underlying fascin-mediated cancer metastasis. This review will cover the biochemical basis for fascin-bundling activity, the mechanisms by which cancer cells upregulate fascin expression and the mechanism underlying fascin-mediated cancer cell migration, invasion, and metastatic colonization. We propose that fascin has broad roles in both metastatic dissemination and metastatic colonization. Understanding these mechanisms will be crucial to the development of anti-metastasis therapeutics targeting fascin.
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