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Kasper Bendix Johnsen et al.
SCIENTIFIC REPORTS (2017)
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Dag Sehlin et al.
SCIENTIFIC REPORTS (2017)
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EXPERT OPINION ON BIOLOGICAL THERAPY (2016)
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EXPERT OPINION ON DRUG DELIVERY (2016)
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Carl I. Webster et al.
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NATURE (2016)
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Y. Joy Yu Zuchero et al.
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Dag Sehlin et al.
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Andrew J. Clark et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Amyloid-β-directed immunotherapy for Alzheimer's disease
L. Lannfelt et al.
JOURNAL OF INTERNAL MEDICINE (2014)
Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle
Jens Niewoehner et al.
NEURON (2014)
Automated functional characterization of radiolabeled antibodies: a time-resolved approach
Ellen Wang et al.
NUCLEAR MEDICINE COMMUNICATIONS (2014)
Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier
Jessica A. Couch et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
Y. Joy Yu et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice
Anna Lord et al.
FEBS JOURNAL (2009)
A highly insoluble state of Aβ similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice
Ola Philipson et al.
NEUROBIOLOGY OF AGING (2009)
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
S. Salloway et al.
NEUROLOGY (2009)
The Arctic Alzheimer mutation facilitates early intraneuronal A beta aggregation and senile plaque formation in transgenic mice
A Lord et al.
NEUROBIOLOGY OF AGING (2006)
A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy
Y Ma et al.
NEUROSCIENCE (2005)
Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium
A Muruganandam et al.
FASEB JOURNAL (2001)
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
F Bard et al.
NATURE MEDICINE (2000)
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